This is the personal page of Jacob Leander, Clinical Pharmacometrician at AstraZenceca. I am passionate about mathematical modeling to support decision making in drug development. I am particulary interested in the mixed effects approach, informative time-to-event, joint models, parameter estimation and stochastic models.

News

• 26 May 2023: We are presenting a poster on “Latent process location-scale mixed-effects model for intensively sampled ordinal patient reported outcomes” on NORDSTAT23. Abstract can be found here
• 18 Nov 2021: New paper “A stochastic mixed effects model to assess treatment effects and fluctuations in home-measured peak expiratory flow and the association with exacerbation risk in asthma”, https://doi.org/10.1002/psp4.12748
  
• 15 Sept 2021: New paper “Nonlinear Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems in Wolfram Mathematica”, https://doi.org/10.1016/j.ifacol.2021.08.394
  
• 4 June 2021: I am now officially a Doctor of Philosophy in Applied Mathematics and Mathematical Statistics, after successfully defending my thesis. You can read more about my research project in this interview!
• 4 May 2021: PhD thesis published! The defense will take place on June 4 at 10.00 AM (Swedish time). For additional information, see here
  
• 17 March 2021: New paper “A semi-mechanistic exposure–response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases”, https://doi.org/10.1007/s10928-021-09747-y
  
  Older news