Jacob Leander

Jacob Leander

Publications


    Peer-reviewed papers

  1. Leander, J., Jirstrand, M., Eriksson, U.G., Palmér, R. (2022). A stochastic mixed effects model to assess treatment effects and fluctuations in home-measured peak expiratory flow and the association with exacerbation risk in asthma, CPT: Pharmacometrics and Systems Pharmacology, 11:212-224
  2. Leander, J., Almquist, J., Johnning, A., Larsson, J., Jirstrand, M. (2021). Nonlinear Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems in Wolfram Mathematica, IFAC-PapersOnLine 54(7) 409-414
  3. Leander, J., Sunnåker, M., Rekić, D., Aksenov, S., Eriksson, U.G., Johansson, S., Parkinson, J. (2021). A semi-mechanistic exposure–response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases, Journal of Pharmacokinetics and Pharmacodynamics 48, 525-541
  4. Rekić, D., Johansson, S., Leander, J. (2021). Higher Febuxostat Exposure Observed in Asian Compared with Caucasian Subjects Independent of Bodyweight, Clinical Pharmacokinetics 60, 319-328
  5. Almquist, J. Sadiq, M.W., Eriksson, U.G., Hegelund-Myrbäck, T., Prothon, S., Leander, J. (2020). Estimation of equipotent doses for anti-inflammatory effects of prednisolone and AZD9567, an oral selective non‐steroidal glucocorticoid receptor modulator, CPT: Pharmacometrics & Systems Pharmacology, 9(8), 444-455
  6. Hegelund-Myrbäck, T., Prothon, S., Edman, K., Leander, J., Hashemi, M., Dearman, M., Edenro, G., Svanberg, P., Andersson, E-M., Almquist, J., Ämmälä, C., Hendrickx, R., Taib, Z., Johansson, K, Berggren, A, Keen, C., Eriksson, U.G., Fuhr, R., Carlsson, B. (2020). Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials, Lancet Rheumatology, 2(1), 31-41
  7. Olafsdotir, H.K, Leander, J., Almquist, J., Jirstrand, M. (2018). Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics, The AAPS Journal 20, 88
  8. Almquist, J., Leander, J., Jirstrand, M. (2015). Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood, Journal of Pharmacokinetics and Pharmacodynamics, 42(3), 191-209
  9. Leander, J., Almquist, J., Ahlström, C., Gabrielsson, J., Jirstrand, M. (2015). Mixed effects modeling using stochastic differential equations: illustrated by pharmacokinetic data of nicotinic acid in obese Zucker rats, The APPS Journal, 17(3), 586-596
  10. Tapani, S., Almquist, J., Leander, J., Ahlström, C., Peletier, L.A., Jirstrand, M., Gabrielsson, J., (2014). Joint feedback analysis modeling of nonesterified fatty acids in obese Zucker rats and normal Sprague–Dawley rats after different routes of administration of nicotinic acid, Journal of Pharmaceutical Sciences, 103(8), 2571-2584
  11. Leander, J., Lundh, T., Jirstrand, M. (2014). Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements, Mathematical Biosciences, 251, 54-62

    Theses

  12. PhD thesis (2021). Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems - Methods and Applications in Drug Development
  13. Licentiate thesis (2014). Contributions to nonlinear mixed-effects modeling
  14. Master thesis (2012). Optimal design of clinical studies using the PFIM software